Theophylline Toxicokinetics in Premature Newborns
نویسندگان
چکیده
منابع مشابه
Theophylline toxicokinetics in premature newborns.
BACKGROUND While cytochrome P4501A2 is the primary pathway for theophylline (aminophylline ethylenediamine) metabolism in adults, it is developmentally immature in the newborn. OBJECTIVE To report the developmental differences in theophylline toxicokinetics of neonates. DESIGN Case series. Three premature neonates received inadvertent intravenous overdoses of theophylline for apnea of prema...
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Introduction MRI techniques have recently demonstrated the ability to provide valuable anatomic imaging in the newborn brain, but additional metabolic markers would be important to provide improved assessments of neonatal brain injury. 3D point-resolved spectroscopic imaging (PRESS-MRSI) can provide accurate measurements of metabolite levels throughout the brain, but it is more complex than com...
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Neonatal liver abscess is a very rare condition associated with high morbidity and mortality rates. There seems to be an increasing trend of this rare condition amongst the newborns admitted to neonatal intensive care units. We report a case of liver abscess in a premature newborn and briefly review the literature and discuss its management.
متن کاملWhite Matter Injury in Premature Newborns.
Preterm newborns are highly susceptible to brain injury. White matter injury is among the dominant patterns of brain injury in preterm newborns. the purpose of this review is to discuss the pathogenesis, diagnosis, management, and prevention of white matter injury in premature newborns. the long-term outcome of white matter injury in children born prematurely is also addressed.
متن کاملOlfactory stimulation prevents apnea in premature newborns.
OBJECTIVE Methylxanthines and doxapram are currently used to treat apnea of prematurity but are not fully effective and often present undesirable side effects. The present study examines whether exposure to an odor known to modulate the infant's respiratory rate could reduce the frequency of apneic spells. METHOD Fourteen preterm newborns born at 24 to 28 gestational weeks presenting recurren...
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ژورنال
عنوان ژورنال: Archives of Pediatrics & Adolescent Medicine
سال: 2001
ISSN: 1072-4710
DOI: 10.1001/archpedi.155.8.934